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KMID : 1123920160300060419
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Korean Journal of Oriental Physiology and Pathology
2016 Volume.30 No. 6 p.419 ~ p.425
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Review of Network Pharmacological Approaches on Korean Medicine
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Beck Jong-Min
Seo Han-Kil
Kwon Young-Kyu
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Abstract
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This study analyzed research methodologies based on network pharmacology to build a new system architecture optimized for Korean Medicine research. Results form studies using network pharmacology were collected and analyzed to evaluate the strength and weakness. Finally, an improved system architecture was proposed. Whether the predicted effects of drugs or herbs from network pharmacological analyses were in agreement with those from conventioanl knowledge of Korean Medicine was evaluated. These results were used to verify the applicability of research methodologies to the modern pharmacology and Korean Medicine respectively. Eighteen papers using TCMSP were collected and analyzed. The results suggest that the research methodology based on network pharmacology is appropriate only for the modern pharmacology but not for Korean Medicine. Information about compound-compound, herb-herb and drug-compound interactions need to be considered. We propose the modified system architecture with those information.
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KEYWORD
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Network pharmacology , Systems biology , TCM , Efficacy research , Research methodology
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